The Expertise of Bio Elpida in Eukaryotes Cell Culture
Isolation, cloning and large-scale culture for the production of proteins of interest

Bio Elpida has the facilities, equipments and expertise to handle eukaryote cell culture projects:
  • Isolation
  • Cloning
  • Large-scale culture…

Upstream step – Culture

For upstream steps, Bio Elpida recommends a Single-Use approach.

The techniques used are adapted to cell suspensions as well as adhesive cells. The culture volume will depend on the project and can range from small volumes (100ml) to the manufacturing of pre-industrial clinical batches (20l or more depending of the technology).

In addition, Bio Elpida proposes to optimise culture conditions, including medium composition.

Downstream step – Purification of API

Bio Elpida can also organise and/or participate in all downstream steps necessary to the "production" of antibodies or proteins of interest obtained by cell culture:
  • Clarification by classical techniques such as filtration and cycles of ultra-filtrations
  • Purification by liquid chromatography of antibodies and of protein of interest with equipments that are compatible with development and also with the manufacturing of pre-clinical or phase I/II clinical batches
  • Inactivation and sterilisation with viral inactivation by ultrafiltration/diafiltration, nanofiltration or chemical inactivation (solvent, detergent, pH…)

All these operations can be performed in the pharmaceutical zone.

Bio Elpida

Founded in 2009, Bio Elpida is a Biotechnology Contract Manufacturing Company specialised in the development and manufacturing of innovative cell therapies.

The expertise of the company covers 3 areas:
In these areas, Bio Elpida offers services that include:
Bio Elpida is the first French laboratory certified by the French Health Authorities (MSNA) as a Pharmaceutical Company and authorised to manufacture Active Pharmaceutical Ingredients for experimental biological pharmaceuticals.

Bio Elpida - 97 allée Alexandre Borodine - Bâtiment 5 Cèdre 1 - 69800 Saint Priest - FRANCE - Phone: +33 (0)4 78 47 02 70 - Mail: infos@bio-elpida.com
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