Bio Elpida Pharmaceutical Support Services

Bulk Purification of Cell Based Product

Based on its deep cell culture expertise, Bio Elpida can also provide bulk production and purification. We recommend using SUB (Single Use Bioreactor) and propose different production means such as perfusion by ultra filtration or continuous centrifugation or simply by batch.

Hence, Bio Elpida can also develop biomolecules purification techniques and methods such as proteins or monoclonal antibodies.

The different purification steps proposed are as follows:

• Bulk clarification
• Concentration and diafiltration by ultra filtration
• Capture (charge induction hydrophobic interaction chromatography)
• First purification (affinity, ion exchange, hydrophobic chromatography)
• Finale purification (to reach a high purity degree)
• Formulation
• Filling